Michael J. Landowski, PhD

Michael J. Landowski, PhD

T32 Vision Research Trainee

landowski@wisc.edu

trainer:

Akihiro Ikeda, PhD

research:

As a postdoctoral trainee in the lab of Dr. Aki Ikeda, Dr. Landowski will investigate the molecular pathways disrupted by genetic mutations that accelerate the formation of age-dependent retinal pathologies in mice.  His studies will focus on mice with a mutation in transmembrane protein 135 (Tmem135) that display age-dependent retinal pathologies such as RPE abnormalities, photoreceptor degeneration and visual loss.  TMEM135 is a mitochondria-associated protein believed to regulate mitochondria dynamics, but the mechanism by which TMEM135 protects an eye from age-dependent pathologies is unknown.  Working with Dr. Ikeda, he will use genetic techniques to identify and interrogate pathways perturbed by the TMEM135 deficiency in mice.